Expression of the estrogen-related receptor 1 (ERR-1) orphan receptor during mouse development

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Expression of the estrogen-related receptor 1 (ERR-1) orphan receptor during mouse development

We studied the expression of the estrogen-related receptor 1 (ERR-1) during mouse embryonic development. ERR-1 is expressed at very early stages in ES cells and at E8.5 in the mesodermal cells of the visceral yolk sac. ERR-1 continues to be expressed later in mesodermal tissues and particularly in heart and in skeletal muscles. This expression persists during all the embryonic development and i...

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The estrogen-related receptor (ERR ) functions in PPAR coactivator 1 (PGC-1 )-induced mitochondrial biogenesis

Estrogen-related receptor (ERR ) is one of the first orphan nuclear receptors to be identified, yet its physiological functions are still unclear. We show here that ERR is an effector of the transcriptional coactivator PGC-1 [peroxisome proliferator-activated receptor (PPAR ) coactivator 1 ], and that it regulates the expression of genes involved in oxidative phosphorylation and mitochondrial b...

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Human ERRgamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult.

The nuclear receptor protein superfamily is a large group of transcription factors involved in many aspects of animal development, tissue differentiation, and homeostasis in the higher eukaryotes. A subfamily of receptors, ERRalpha and beta (estrogen receptor-related receptor alpha and beta), closely related to the ER, were among the first orphan nuclear receptors identified. These receptors ca...

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Estrogen receptor gene 1 expression in caprine and its effect on fertility

The present study was undertaken to analyze the expression pattern of estrogen receptor 1 gene (ESR1) in Barbari bucks (fertile and non-fertile) identified on the basis of seminal quality traits and fertility trials. RNA was extracted from the spleen by Trizol method. The expression pattern of ESR1 gene was analyzed using real time polymerase chain reaction (RT-PCR). The expression pattern of E...

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Developmental expression of the estrogen receptor-related receptor γ in the nervous system during mouse embryogenesis

The ERR's (estrogen receptor-related receptors) are constitutive activators of the classical estrogen response element. In this report, we demonstrate that ERRgamma is highly expressed in the nervous system of the developing mouse embryo and that the adult pattern of expression of ERRgamma is, with few exceptions, established during embryogenesis. Transcripts are preferentially detected in alre...

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ژورنال

عنوان ژورنال: Mechanisms of Development

سال: 1997

ISSN: 0925-4773

DOI: 10.1016/s0925-4773(97)00059-2